Blackfoot disease (BFD) is a severe form of peripheral vascular disease (PVD), in which the blood vessels in the lower limbs are severely damaged, resulting eventually in progressive gangrene. It has been observed in certain areas along the southwestern coast of Taiwan where the average concentration of dissolved arsenic in the wells is 671 ± 149 µg/L with an average As(III)/As(V) ratio of 2.6. The first symptons of the disease are the spottet discoloration of the skin on the feet that turns from brown to black as the disease develops until amputation of the affected extremities, the final resort to save the BFD victims, becomes necesaary.