Organosilicon compounds are man-made organic compounds containing carbon silicon bonds. Organosilicon chemistry is the corresponding science exploring their properties and reactivity.

Like carbon, the organically bound silicon is tetravalent and tetrahedral. Carbon-silicon bonds are not found in any biomolecule.The first organosilicon compound, tetraethylsilane was discovered by Charles Friedel and James Crafts in 1863 by reaction of tetrachlorosilane with diethylzinc.