Ceruloplasmin is a large protein with a molecular weight of 132,000 daltons and the main copper-binding protein in blood plasma. Each molecule will bind six atoms of copper, containing type 1, type 2 and type 3 copper centers, where the type 2 and type 3 are close together, forming a trinuclear copper cluster. Low values of ceruloplasmin are found in Wilson's disease, malnutrition and Menke's kinky hair syndrome. Elevated levels are found during pregnancy, estrogen or anti-seizure drug use, infections, tissue necrosis and trauma.