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Instrument Database:
Applied Biosystems - API 4000™ LC/MS/MS System
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| Year of introduction |
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| Status |
available |
| Company |
Applied Biosystems
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| Categories |
Hyphenated Techniques: LC-MS
Mass spectrometer: ESI-MS
Mass spectrometer: LC-MS
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The industry-standard API 4000™ LC/MS/MS System brings high-performance quantitation and identification to every phase of the pharmaceutical development process, from discovery to clinical research trials. - Proven Curtain Gas™ interface technology, combined with improved gas dynamics, reduces maintenance and increases uptime.
- Enhanced high flow-rate performance, reduced ionization suppression, self-cleaning probe design, and reliable interface all combine for accelerated productivity and high throughput.
- Windows NT® platform-based Analyst® software facilitates GLP compliance, including 21 CFR Part 11.
Low Limits of Detection
The high sensitivity of the API 4000™ system ensures low detection limits. Efficient ionization and superior ion sampling of the interface result in excellent sensitivity.
Flexible Options Increase Throughput
Easy-to-use TURBO V™ source allows you to quantitate over a wide range of flow rates and to change rapidly between atmospheric pressure chemical ionization (APCI) and TurboIonSpray® probes. The optional DuoSpray™ ion source accelerates method development and increases both throughput and data quality. An additional option for atmospheric pressure photo-ionization, the PhotoSpray source, expands the range of compounds you can analyze.
Automated Data Acquisition
Innovative software applications enable automated MS to MS/MS acquisition, allowing you to extract the maximum amount of information from a single LC/MS run.
Rugged, Reliable, and Easy to Use
The superior ionization efficiency, enhanced robustness, and ease of use of the innovative TURBO V™ source, combined with the patented LINAC® collision cell, delivers high performance and high productivity with greater confidence in your results.
Fast, Secure Access to Information for DMPK Studies
Integration with Analyst® software's powerful data acquisition and processing capabilities provides fast and secure access to the information you need for DMPK studies.
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| Specifications |
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| System Set-Up Specifications |
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| Gas Supplies | Gas Supplies: 60 psi high purity nitrogen, 100 psi zero grade air, 60 psi filtered, dry air
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| Performance/Throughput | | Mass Accuracy | 0.01% over the entire mass range
| | Dynamic Range | 1 cps to 4 x 106 cps (pulse counting)
| | Mass Range | m/z 5-3,000
| | Physical Specifications | | Width | 130 cm (53 in)
| | Depth | 50 cm (20 in)
| | Weight | 136 kg (299.2 lb)
| | Height | 52 cm (21.5 in)
| | Computer Requirements (PC) | | Operating System | Windows 2000/XP
| | CD-ROM | CVC RW (CD RW capable)
| | Memory | 1 GB RAM
| | CPU | 3.2 GHz
| | Hard Disk | 200GB
| | Display | 19" Viewable Color monitor recommended
| | Power Requirements | | Voltage | 2 separate 207 V minimum to 242 V maximum
| | Circuit Current | 15 A grounded single phase circuit
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