Synthesis of isotopically labelled compounds with non-conventional (bromine-81, chlorine-37, sulphur-34) and conventional (carbon-13) labels using the concept of minimal labelling in the fields of environmental analysis, food science, clinical chemistry and proteomics.

Development of procedures for the measurement of isotope ratios and molar fractions (isotope pattern deconvolution) between labelled and unlabelled compounds by Mass Spectrometry in fields such as Chemical Metrology (environmental analysis and clinical chemistry), Biology (metabolism of trace elements), Biochemistry (quantitative proteomics) and Medicine (development of clinical tests based on enriched isotopes).

Development and application of analytical instrumentation for the traceability assessment of pure compounds to the International System of units using post-column isotope dilution analysis with carbon-13 enriched carbon dioxide.

Support to other research groups requiring isotopic measurements in Agricultural Chemistry, Archaeometry and Geosciences and for the traceability assessment of manufactured goods.

Development of patents and applications based on the use of enriched stable isotopes which could have high added value such as in the traceability of explosives, the isotopic labelling of jewels, the detection of frauds and the development of absolute analytical procedures and related analytical instrumentation.