The establishment of EVISA is funded by the EU through
the Fifth Framework Programme (G7RT- CT- 2002- 05112).
Supporters of EVISA includes:
mean residence time (in pharmaco- and toxicokinetics) (MRT)
Average time a substance remains in an animal body or an organ after rapid intravenous injection. Note 1: Like clearance, its value is independent of dose in most cases. Note 2: After an intravenous bolus tr= Am/A where tr is the MRT, A is the area under the plasma concentration-time curve, and Am is the area under the moment curve. Note 3: For a drug with one-compartment distribution characteristics, MRT equals the recipro- cal of the elimination rate constant.