Safe Use of Nickel in the Workplace: Pharmacokinetics of Nickel Compounds
4. PHARMACOKINETICS OF NICKEL COMPOUNDS
4. PHARMACOKINETICS OF NICKEL COMPOUNDS
Factors of biological
importance to nickel, its compounds, and alloys include solubility,
chemical form (species), physical form (e.g. massive versus
dispersible), particle size, surface area, concentration, and route and
duration of exposure. Where possible, the relationship of these factors
to the intake, absorption, distribution, and elimination of nickel is
discussed in this section. Independent factors that can also affect the
biokinetic activity of nickel species, such as disease states and
physiological stresses, are briefly noted.