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Material Database:
Se-(Methyl)selenocysteine Hydrochloride
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| Type |
Chelating compound |
| Producer |
SUPELCO by Sigma-Aldrich
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| Status |
Available |
| Material |
Solid |
| Reference |
M6680 |
| Catalog (Web) |
http://www.sigmaaldrich.com/catalog/search/ProductDetail/S
IGMA/M6680 |
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Description
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≥95% (TLC) Molecular Formula C4H9NO2Se · HCl
Molecular Weight 218.54
Biochem/physiol Actions Chemopreventive agent that blocks cell cycle progression and proliferation of premalignant mammary lesions and induces apoptosis of cancer cell lines in culture.
Properties
storage temp. −20°C
Safety
Hazard Codes T,N
References:
Ip, C., et al., New concepts in selenium chemoprevention. Cancer Metastasis Rev. 21, 281-289, (2002) Whanger, P.D., Selenium and its relationship to cancer: an update dagger. Br. J. Nutr. 91, 11-28, (2004)
Yeo, J.K., et al., Se-methylselenocysteine induces apoptosis through caspase activation and Bax cleavage mediated by calpain in SKOV-3 ovarian cancer cells. Cancer Lett. 182, 83-92, (2002)
Spallholz, J.E., et al., Dimethyldiselenide and methylseleninic acid generate superoxide in an in vitro chemiluminescence assay in the presence of glutathione: implications for the anticarcinogenic activity of L-selenomethionine and L-Se-methylselenocysteine. Nutr. Cancer 40, 34-41, (2001)
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