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Instrument Database:
Caliper Life Sciences - MultiDose® G3 Automated Dissolution Analysis
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| Year of introduction |
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| Status |
available |
| Company |
Caliper Life Sciences
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| Categories |
Sample preparation: Dissolution systems
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The MultiDose G3 is the only fully-automated dissolution system that works within an open architecture, allowing the use of industry standard accessories in a wide variety of configurations. MultiDose G3 performs 8 unattended dissolution runs of different methods and configurations without intervention.
MultiDose G3 Plus provides the added capability of running methods requiring baskets (USP I) and sinkers.
Benefits:
- A MultiDose G3 used at 50% of its capacity can add the resources equivalent of approximately two analysts
- Frees valuable time for analysts to work on more value-added projects and tasks
- Automated dissolution increases productivity through increased capacity and more consistent, technique independent results
- Advanced media handling capabilities give the G3 the flexibility to address most any method requiring media changes or modifications
- Comprehensive software allows the use of advanced chemometric techniques
- Multiple components can be analyzed within a single dosage form as well as between vessels
- Easy method transfer to other laboratories that have G3
- USP and 21CFR11 compliant operating system provides secure data
- Audit trail helps make the investigation of out of specification results more efficient
- Network capability allows data management and reporting activities to be conducted from an environment external to the lab
- Product Configuration
- The open architecture of MultiDose G3 allows it to support a variety of configuration to fully automate most every dissolution testing protocol. The following lists some of the more common configurations:
- MultiDose with Collector/Diluter
- MultiDose with Collector/Diluter X2
- MultiDose with Flow-through UV
- MultiDose with Flow-through UV and Sample Collector
- MultiDose with Sample Collector/Diluter, and HPLC.
- MultiDose with Collector/Diluter and UV or Fluorescence
- MultiDose with Re-circulation Flow-through UV
- MultiDose with Re-circulation Collector
Supplemental Media for media modification can be added to any configuration (recommended for USP type II methods). Coming soon will be the ability to add in-line pH measurement to any configuration.
Supported Third Party Accessories:
- Baths
- VanKel
- Hanson
- Distek
- UV Spectrophotometers
- Varian
- Agilent
- Perkin Elmer
- Shimadzu
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| Specifications |
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Sample Capacity:
Eight Unattended Dissolution Runs
Number of Media:
1 Deionized Water and 1 Auxiliary Media
4 - with 4 way Auxiliary Media Switching Valve
Deionized Water Inlet:
40 psi max, 1 L/min minimum flow rate
Vessel Wash:
Hot Water, 80psi, 120°F Max
Sparge Gas:
Helium, 30 psi max
Vessel Fill Range:
500 - 1000ml
Vessel Fill Accuracy:
Exceeds USP Specification
Media Tank Balance:
+/- 1g Accuracy
Dissolution Testers Supported:
Distek 2100B/2100C, Hanson SR8,
VanKel 7000, Erweka DT70, DT80
Spectrophotometers Supported:
Agilent, PE Lambda, Shimadzu, Varian
Filtration:
25 mm Syringe Filter, Automation Certified
Millipore Filters Recommended
Sampling Flow Rate:
5.0 ml/min to 12 ml/min
Sample Disposition:
Fraction Collection or On-line UV/VIS
MultiFill Fraction Collector:
21 Fractions with 13 x 100 mm Test Tubes
21 Fractions with 16 x 100 mm Test Tubes
24 Fractions with 11 mm Vials
24 Fractions with 4 ml WISP Vials
All doubled with Extended MultiFill Option
Fraction Collectors Supported:
Caliper Life Sciences MultiFill, Gilson 232
Data Output to External
Computer:
Required PC that Supports Windows 95,
Windows 2000, Windows NT and Excel 7.0
Power:
120 VAC at 10 Amps
220/240 VAC at 5 Amps
Baskets:
Van Kel Authorized
Wire Sinker:
Teflon Coated Metal
Benchspace Requirement:
83" Linear Array
57" Non-linear Arrangement Plus Allowances
for UV, MultiFill, Dissolution Bath and other
Accessories
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