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Instrument Database:
Thermo Scientific - Orbitrap Velos Pro™ Hybrid Ion Trap-Orbitrap Mass Spectrometer
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| Year of introduction |
2009 |
| Status |
available |
| Company |
Thermo Scientific
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| Categories |
Hyphenated Techniques: LC-MS
Mass spectrometer: ESI-MS
Mass spectrometer: LC-MS
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Analyze proteomics and metabolomics samples rapidly and with confidence using the Thermo Scientific™ Orbitrap Velos Pro™ Hybrid Ion Trap-Orbitrap Mass Spectrometer. This instrument combines a Thermo Scientific™ Orbitrap ™ mass analyzer and Velos Pro ion trap technology to deliver high resolution, speed, sensitivity, and flexibility.
Performance
- Resolving power up to 100,000 FWHM and mass accuracy better than 1ppm RMS provide confidence when analyzing complex samples
- Multiple fragmentation techniques—CID, HCD, and optionally ETD—offer versatility and facilitate structural characterization
- Fast scanning and parallel MS and MSn analysis speeds analyses
- Ion optics with novel neutral-blocking technology increase robustness
- Collision cell with axial field gradient improves quantitative results
Flexible Proteomics Analyses
- High mass resolution and mass accuracy enable high-confidence molecular weight determination of intact proteins, peptide identification in complex samples and analysis of isobaric species
- High sensitivity increases detection of low-abundance peptides and proteins
- Short duty cycle increases sequence coverage within in a single experiment
- Stability, mass accuracy and wide dynamic facilitate label-free quantification
- Mass resolution and mass accuracy distinguish between heavy and light peptide ion pairs and interferences in SILAC experiments
- HCD cell with axial field improves quantification of isobarically labeled peptides
- Optional electron-transfer dissociation (ETD) generates complementary information for P™ analyses and de novo sequencing
Confident Metabolism and Metabolomics
- High mass resolution and mass accuracy and wide dynamic range enable confident identification low-level metabolites in complex biological matrices
- Complementary dissociation methods—CID MSn spectral trees and HCD MS/MS—facilitate unambiguous structural elucidation
- High sensitivity and fragmentation efficiency as well as short cycle times lower limits of detection and quantification while improving the quality of the ion-tree experiments for structural elucidation
- HCD collision cell provides comprehensive fragmentation information for small molecule structural analysis
Application Software
- Thermo Scientific™ Mass Frontier™, MetWorks™, ProMass™ Deconvolution, ProSightPC, Proteome Discoverer™ and SIEVE™ software and PEAKS™ software are available to increase data analysis productivity.
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