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Instrument Database:
Thermo Scientific - Exactive™ Plus EMR Orbitrap™ LC-MS System
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| Year of introduction |
2013 |
| Status |
available |
| Company |
Thermo Scientific
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| Categories |
Hyphenated Techniques: LC-MS
Mass spectrometer: ESI-MS
Mass spectrometer: LC-MS
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The Thermo Scientific™ Exactive™ Plus EMR mass spectrometer combines unsurpassed high-resolution accurate-mass Thermo Scientific™ Orbitrap™ analysis with an extended mass range (EMR) option to create an outstanding tool for investigating the structure, topology, and architecture of native-like tertiary and quaternary protein structures.
Confidently Identify, Characterize, and Quantify Intact Proteins
- Extended m/z 350–20,000 mass range enables analysis of larger proteins, antibodies, antibody-drug conjugates, glycoforms, and protein assemblies
- Improved transmission of higher-mass ions provides stronger signals
- Resolving power up to 140,000 FWHM enables separation of isoforms and determination of glycosylation states
- Excellent mass accuracy ensures confident identification
- Access to shor transients improves signal-to-noise ratios
- Compatibility with Thermo Scientific Protein Deconvolution software designed specifically for identification and characterization of intact proteins
Easy-to-Use
- Modified HCD cell controls make it easier to optimize experimental conditions
- Intuitive operating software reduces learning curves
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| Specifications |
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Mass Range
| m/z 350 to 20,000
| Dynamic Range
| >5000:1 in single scan, intrascan dynamic range
| Mass Accuracy
| <5ppm for m/z 6001 to 10,000
| Polarity Switching
| One full cycle in <1s (one full scan positive mode and one full scan negative mode) at resolution 35,000 at m/z 200
| Sensitivity
| In full-scan MS mode: 500fg buspirone on-column S/N 100:1 acquired with H-ESI II probe
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