Scale-up in a bench top reactor
Masterwave BTR has been developed and evaluated in cooperation with globally active pharmaceutical companies and reaches a new level in microwave-assisted organic synthesis. It combines utmost user safety and facilitation of daily lab-work with the highest Anton Paar standards. For the first time microwave synthesis can be moved into the kilolab. Scalability and reproducibility have been explored at high accuracy for a broad diversity of reactions.
Sophisticated temperature measurement
In order to avoid handling of fragile immersion tubes, the system is equipped with a rising Pt100 sensor in the bottom of the cavity. Via an inverted sleeve at the bottom of the PTFE liner the sensor immerses into the reaction vessel measuring the internal reaction temperature. Due to the large volumes processed, measurement with the Pt100 sensor is as fast as a fiber optic probe system.
Patent-pending microwave applicator
The multimode microwave cavity has a patent-pending design in which up to 750 mL reaction mixture is heated in a 1-L PTFE reaction vessel. Two magnetrons create up to 1700 W of microwave power which is guided into the compact cavity where the high field density ensures impressive heating rates up to the limits of 250 °C and 30 bar.
Independent stirring regime
Masterwave BTR is the only microwave reactor which is equipped with a stirring sensor that automatically detects whether the agitator is moving or not. Consequently, it will find the optimum stirring speed in a self-acting way and it adjusts itself accordingly for each experiment. This individual stirring regime ensures homogeneous temperature distribution as well as effective mixing of the reaction components.
Fast and effective cooling of the reaction mixture is accomplished by a continuously circulating cooling liquid. This system keeps the entire reactor on a moderate temperature level. When microwave irradiation is off the reaction mixture will be cooled within 10 to 15 minutes (solvent- and volume dependent). This cooling system is also part of the safety concept, as the vessel is cool and at atmospheric pressure when taken out of the cavity.