Catalytic MetalloDrugs

• Design of metallodrugs against structured RNA target motifs from viral and bacterial pathogens and elaboration of the structural, thermodynamic and kinetic principals underlying recognition and reaction chemistry.
• Design of metallodrugs against protein and enzyme targets related to cardiovascular disease, Alzheimers, HCV and HIV, and cancer. Studies to include elaboration of the structural, thermodynamic and kinetic principals underlying recognition and reaction chemistry.
• Cellular assays of metallodrug activity using fluorescent and colorimetric reporters.