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Instrument Database:
Thermo Scientific - Orbitrap Elite™ Hybrid Ion Trap-Orbitrap Mass Spectrometer
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| Year of introduction |
2011 |
| Status |
available |
| Company |
Thermo Scientific
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| Categories |
Hyphenated Techniques: LC-MS
Mass spectrometer: ESI-MS
Mass spectrometer: LC-MS
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Analyze demanding proteomics, metabolomics, lipidomics and metabolism samples in greater depth using the Thermo Scientific™ Orbitrap Elite™ Hybrid Ion Trap-Orbitrap Mass Spectrometer. This instrument combines a high-field Thermo Scientific™ Orbitrap ™ mass analyzer and Thermo Scientific™ Velos Pro™ ion trap technology to deliver very high resolution, speed, sensitivity and complementary fragmentation information.
Performance
- Very high resolving power—up to 240,000 FWHM—facilitates analysis of low-abundance components in complex samples and resolves isobaric species and isotope fine structures with confidence
- Ion optics with novel neutral-blocking technology and an advanced detection system increase system robustness and quantification capabilities
- Advanced signal processing combined with fast scanning ensures UHPLC compatibility
- Multiple fragmentation techniques—CID, HCD and optionally ETD—provide versatility and complementary data
- Innovative pre-amplifier electronics improve sensitivity
- Parallel MS and MSn capability speeds analyses
Comprehensive Proteomics Analyses
- Very high resolution and complementary fragmentation modes facilitate top-down protein identification and characterization
- ETD option preserves labile side chains while fragmenting the peptide backbone for improved analysis of P™s
- Fast scanning combined with high resolution and high spectral quality yields more protein identifications in a single analysis
- Very high resolution and selectivity in both full-scan MS and MSn modes enhance relative quantification results from stable isotope labeling or isobaric mass tagging experiments
Productive Metabolism and Metabolomics Research
- Very high resolution distinguishes components in complex matrices
- Sensitivity ensures detection of more metabolites
- High-quality MSn spectral trees provide extensive structural information for metabolite identification and the location of modification sites
- Improved robustness lowers maintenance, enabling 24/7 operation when running complex biological matrices
Application-Specific Software
- Thermo Scientific™ Mass Frontier™, MetWorks™, ProSightPC, ProteinCenter™, Proteome Discoverer™ and SIEVE™ software as well as PEAKS™ software are all available to increase productivity for specific tasks or applications.
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| Specifications |
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| Mass Range | 50 to 2000m/z
200 to 4000m/z | Dynamic Range
| >5000 within a single scan guaranteeing specified
| | MS Scan Power | MSn for n = 1 through 10
| Mass Accuracy
| <3ppm RMS with external calibration;
<1ppm RMS using internal calibration
| Resolution
| 60,000 at m/z 400 at a scan rate of 4Hz, min. resolution 15,000, max. resolution >240,000 at m/z 400
| Voltage
| 230V
| Weight
| (Metric) 620kg
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