cisplatin

Cisplatin is a "first generation" antitumor drug highly effective in the chemotherapy of many forms of cancer. Thge metallodrug is most commonly used to treat testicular, bladder, lung, gullet (oesophagus), stomach and ovarian cancers. The water-soluble platinum complex, after hydrolysis, reacts with the nucleic acid bases of DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
 
IUPAC name: cis-diamminedichloroplatinum(II).



The term "cisplatin" was found in the following pages:

Side effects of cisplatin chemotherpy: Platinum speciation matters | EVISA's News
Metallomics 2011: Chemiker der Universität Münster laden zu Symposium über die Rolle von Metallen in Biologie und Medizin ein | EVISA's News
Speciation and Toxicity | EVISA's News
Link database: DrugBank: Cisplatin
Dartmouth researchers find that arsenic triggers unique mechanism in rare leukemia | EVISA's News
Copper molecule shows promise in fighting against cancer | EVISA's News
Link database: DrugBank: Oxaliplatin
Link database: Austria: University of Vienna: Institute of Inorganic Chemistry: Working group of B. Keppler
Link database: Lipoplatin -
„Forever young“ oder wirklich jung? - Metallomics im Fokus der Biochemie | EVISA's News
A new quantification strategy for bioimaging by laser ablation - inductively coupled plasma-mass spectrometry based on isotope dilution analysis | EVISA's News
Chemical speciation analysis for the life sciences | EVISA's News
Link database: Australia: University of Western Sydney: Biologically Active Drugs by Design Group
Brief summary: Speciation analysis for the study of metallodrugs and their biomolecular interactions | EVISA's News
Nanoscale Metal-Organic Frameworks (NMOFs): A new way to create better MRI Contrast Agents | EVISA's News
Link database: ChemCases: Cisplatin: The Invention of an Anticancer Drug
Ultra-sensitive speciation analysis of inorganic platinum-chloride complexes in platinum-based drugs by HPLC-ICP-MS | EVISA's News
Link database: Cisplatin, Carboplatin, and Oxaliplatin Interactions With Plasma Proteins
Spatially resolved speciation analysis: A new technique based on laser ablation with simultaneous elemental and molecular mass spectrometry | EVISA's News
Link database: Speciation, bioavailability and antigenotoxicity of Selenium species present in Selenium enriched natural products.