Scientific publications with participation of EVISA
EVISA is not only informing about all aspects of chemical speciation but is actively promoting research in this field.
Research supported by EVISA is meant to:
provide easy and robust methods for speciation analysis
enhance the quality of analytical results and the information provided by speciation analysis
enhance the knowledge about the biological activity, function and toxicity of chemical species
The following studies were done with EVISA participation (newest first):
2024
Maximilian Horstmann, C. Derrick Quarles Jr., Steffen Happel, Michael Sperling, Andreas Faust, David Clases, Uwe Karst, Quantification
of [99Tc]TcO4 in wastewater by means of automated on-line extraction chromatography - anion‑exchange
chromatography – inductively coupled
plasma–mass spectrometry, J. Anal. At. Spectrom., 39/11 (2024) 2774-2782. DOI: 10.1039/d4ja00270a
Katharina Kronenberg, Emily Hoffmann, Lena Hiddeßen, Bastian Maus, Mirjam Gerwing, Cornelius Faber, Michael Sperling, Moritz Wildgruber, Uwe Karst, P-based referencing for correcting tissue artifacts in laser ablation-inductively coupled plasma-mass spectrometry imaging of cancer samples, Metallomics , 16 (2024) mfae034. DOI: 10.1093/mtomcs/mfae034
Maximilian Horstmann, C. Derrick Quarles Jr., Steffen Happel, Michael Sperling, Andreas Faust, Kambiz Rahbar, David Clases, Uwe Karst, Quantification of [99Tc]TcO4 in urine by means of anion‑exchange chromatography–aerosol desolvation nebulization–inductively coupled plasma–mass spectrometry, Anal. Bioanal. Chem., 416 (2024) 2849–2858. DOI: 10.1007/s00216-024-05149-4
2023
Matthias Elinkmann, Sarah Reuter, Michael Holtkamp, Steffen Heuckeroth, Alexander Köhrer, Katharina Kronenberg, Michael Sperling, Oliver Rubner, C. Derrick Quarles, Jr, Michael Hippler, Uwe Karst, Improving detection thresholds and robust event filtering in single-particle and single-cell ICP-MS analysis†, J. Anal. At. Spectrom., 38 (2023) 2607-2618. DOI: 10.1039/d3ja00292f
M. Horstmann, M. Austrup, F. Busch, A. Faust, M. Sperling, U. Karst, D. Clases, Speciation Analysis of Tc radiopharmaceuticals by HPLC-ICP-MS and HPLC-ESI-HRMS, J. Anal. At. Spectrom., 38/10 (2023) 2038-2045. DOI: 10.1039/d3ja00257h
K. Sommer, T. Becker, M. von Bremen-Kühne, M. Gotters, C.D. Quarles, M. Sperling, J. Kudla, U. Karst,Analysis of the elemental species-dependent uptake of lanthanide complexes in Arabidopsis thaliana plants by LA-ICP-MS, Chemosphere, 338 (2023) 139534. DOI: 10.1016/j.chemosphere.2023.139534
2022
Maximilian von Bremen-Kühne, Hassan Ahmadi, Michael Sperling, Ute Krämer, Uwe Karst, Elemental bioimaging of Zn and Cd in leaves of hyperaccumulator Arabidopsis halleri using laser ablation-inductively coupled plasma-mass spectrometry and referencing strategies, Chemosphere 305 (2022) 135267. DOI: 10.1016/j.chemosphere.2022.135267
Olga Reifschneider, Franziska Blaske, Antje Vennemann, Christina Köppen, Michael Sperling, Uwe Karst, Martin Wiemann, Quantitative elemental bioimaging: an antibody-based double-labelling method to quantify the cell-specific distribution of silver nanoparticles in lung tissue sections, J. Anal. At. Spectrom., 37 (2022) 1084-1089. DOI: 10.1039/D1JA00466B
Rebecca Buchholz, Sebastian Krossa, Maria Karoline Andersen, Michael Holtkamp, Michael Sperling, Uwe Karst, May-Britt Tessem, A simple preparation protocol for shipping and storage of tissues sections for LA-ICP-MS imaging, Metallomics, 14 (2022) mfac013. DOI: 10.1093/mtomcs/mfac013.
Lukas Schlatt, Alexander Köhrer, Cécile Factor, Philippe Robert, Marlène Rasschaert, Michael Sperling, and Uwe Karst, Mild
Dissolution/Recomplexation Strategy for Speciation Analysis of
Gadolinium from MR Contrast Agents in Bone Tissues by Means of
HPLC-ICP-MS, Anal. Chem., 93 (2021) 11398−11405. DOI: 10.1021/acs.analchem.1c01100
C. Erbacher, N. Flothkötter, M. Macke, C.D. Quarles, M. Sperling, J. Müller, U. Karst, A fast and automated separation and quantification method for bromine speciation analyzing bromide and 5-bromo-2'-deoxyuridine in enzymatically digested DNA samples via ion chromatography-inductively coupled plasma-mass spectrometry, J. Chromatogr. A, 1652 (2021) 462370. DOI: 10.1016/j.chroma.2021.462370
I.D. Nordhorn D. Dietrich, C. Verlemann, A. Vennemann, R. Schmid, M. Elinkmann, J. Fuchs, M. Sperling, M. Wiemann, U. Karst, Spatially and size-resolved analysis of gold nanoparticles in rat spleen after intracheal instillation by laser ablation-inductively coupled plasma-mass spectrometry, Metallomics, 13/6 (2021) mfab028. DOI: 10.1093/mtomcs/mfab028
Patrick Bücker, Henning Richter, Alexander Radbruch, Michael Sperling, Marcus Brand, Markus Holling, Veerle Van March, Werner Paulus, Astrid Jeibmann, Uwe Karst, Deposition patterns of iatrogenic lanthanum and gadolinium in the human body depend on delivered chemical binding forms, J. Trace Elem. Med. Biol., 63 (2021) 126665. DOI: 10.1016/j.temb.2020.126665
2020
J.M. Will, C. Erbacher, M. Sperling, U. Karst, A mass spectrometry-based approach gives new insights into organotin-protein interactions, Metallomics, 12 (2020) 1702-1712. DOI: 10.1039/D0MT00171F
S. Richter-Brockmann, K. Garbert, M. von Bremen-Kühne, C.A. Wehe, O. Reifschneider, M. Sperling, L. Wallrad, I. Schmitz-Thom, J. Kudla, U. Karst, Elemental bioimaging of Na distribution in roots of Arabisopsis thaliana using laser ablation -ICP-MS under cold plasma conditions, J. Anal. At. Spectrom., 35/9 (2020) 2057-2063. DOI: 10.1039/D0JA00151A
O. Reifschneider. A. Vennemann, G. Buzanich, M. Radtke, U. Reinholz, H. Riesemeier, J. Hogeback, C. Köppen, M. Großgarten, M. Sperling, M. Wiemann, U. Karst, Revealing Silver Nanoparticles Uptake by Macrophages using SR-µXRF and LA-ICP-MS, Chem. Res. Toxicol., 33/5 (2020) 1250-1255. DOI: 10.1021/acs.chemrestox.9b00507
E. Lützen, M. Holtkamp, I. Stamme, R. Schmid, M. Sperling, M. Pütz, U. Karst, Multimodal imaging of hallucinogens 25C- and 25I-NBOMe on blotter papers, Drug Test. Anal., 12 (2020) 465-471. DOI: 10.1002/dta.2751
2019
O.B. Bauer, O. Hachmöller, O. Borovinskaya, M. Sperling, H.-J. Schurek, G. Ciarimboli, U. Karst, LA_ICP-TOF-MS for rapid, all-elemental and quantitative bioimaging, isotopic analysis and the investigation of plasma processes, J. Anal. At. Spectrom., 34/4 (2019) 694-701. DOI: 10.1039/c8ja00288f
S.A.S. van der Bent, T. Berg, U. Karst, M. Sperling, T. Rustmeyer, Allergic reactions to a green tattoo with nickel as a possible allergen, Contact Dermatitis, 81/1 (2019) 64-66. DOI: 10.1111/cod.13226
Jennifer-Christin Müller, Maximilian Horstmann, Lisa Traeger, Andrea U. Steinbicker, Michael Sperling, Uwe Karst, µXRF and LA-ICP-TQMS for quantitative bioimaging of iron in organ samples of a hemochromatosis model, J. Trace Elem. Med. Biol., 52 (2019) 166-175. DOI: 10.1016/j.jtemb.2018.12.012
Sabrina Kröger, Michael Sperling, Uwe Karst, Quantitative dried blood spot analysis for metallodrugs by laser ablation-inductively coupled plasma-mass spectrometry, J. Trace Elem. Med. Biol., 51 (2019) 50-56. DOI: 10.1016/j.jtemb.2018,09.009
David Clases, Stefanie Fingerhut, Astrid Jeibmann, Michael Sperling, Philip Doble, Uwe Karst, LA-ICP-MS/MS
improves limits of detection in elemental bioimaging of gadolinium
deposition originating from MRI contrast agents in skin and brain
tissues, J. Trace Elem. Med. Biol., 51 (2019) 212-218. doi: 10.1016/j.jtemb.2018.10.021
2018
S. Kröger, A.C. Niehoff, A. Jeibmann, M. Sperling, W. Paulus, W. Stummer, U. Karst,Complementary Molecular and Elemental Mass Spectrometry Imaging of Human Brain Tumors Resected by Fluorescence-Guided Surgery, Anal. Chem., 90/20 (2018) 12253-60. doi: 10.1021/acs.analchem.8b03516
Joshua Fuchs, Maryam Aghaei, Tilo Schachtel, Michael Sperling, Annemie Bogaerts, Uwe Karst, Impact of the particle diameter on ion cloud formation from gold nanoparticles in ICP-MS, Anal. Chem., 90/17 (2018) 10271-278. doi: 10.1021/scs.analchem.8b02007
Anna Hucke, Ga Young Park, Oliver B. Bauer, Georg Beyer, Christina Köppen, Dorothea Zeeh, Christoph A. Wehe, Michael Sperling, Rita Schröter, Marta Kantauskaitè, Yohannes Hagos, Uwe Karst, Stephen J. Lippard and Giuliano Ciarimboli, Interaction of the New Monofunctional Anticancer Agent Phenanthriplatin With Transporters for Organic Cations, Front. Chem., 6 (2018) #180. DOI: 10.3389/fchem.2018.00180
Stefanie Fingerhut, Michael Sperling, Markus Holling, Thomas Niederstadt, Thomas Allkemper, Alexander Radbruch, Walter Heindel, Werner Paulus, Astrid Jeibmann, Uwe Karst, Gadolinium‑based contrast agents induce gadolinium deposits in cerebral vessel walls, while the neuropil is not affected: an autopsy study, Acta Neuropathol., 136 (2018) 127-138. DOI: 10.1007/s00401-018-1857
Oliver Bolle Bauer, Christina Köppen, Michael Sperling, Hans-Joachim Schurek, Giuliano Ciarimboli, and Uwe Karst, Quantitative Bioimaging of Platinum via Online Isotope Dilution-Laser Ablation-Inductively Coupled Plasma Mass Spectrometry, Anal. Chem., 90 (2018) 7033−7039. DOI: 10.1021/acs.analchem.8b01429
Jennifer-Christin Müller, Josef Lichtmannegger, Hans Zischka, Michael Sperling, Uwe Karst, High spatial resolution LA-ICP-MS demonstrates massive liver copper depletion in Wilson disease rats upon Methanobactin treatment, Journal of Trace Elements in Medicine and Biology 49 (2018) 119–127. DOI: 10.1016/j.jtemb.2018.05.009
Stefanie Fingerhut, Ann-Christin Niehoff, Michael Sperling, Astrid Jeibmann, Werner Paulus, Thomas Niederstadt, Thomas Allkemper, Walter Heindel, Markus Holling, Uwe Karst, Spatially
resolved quantification of gadolinium deposited in the brain of a
patient treated with gadolinium-based contrast agents, J. Trace Elem. Med. Biol., 45 (2018) 125-130. DOI: 10.1016/j.jtemb.2017.10.004
Georgina M. Thyssen, Claudia Keil, Melanie Wolff, Michael Sperling, Daniel Kadow, Hajo Haase, Uwe Karst, Bioimaging of the elemental distribution in cocoa beans by means of LA-ICP-TQMS, J. Anal. At. Spectrom., 33 (2018) 187-194. DOI: 10.1039/c7ja00354d
2017
G.M. Thyssen, M. Holtkamp, H. Kaulfürst-Soboll, C.A. Wehe, M. Sperling, A. von Schaewen, U. Karst, Elemental bioimaging by means of LA-ICP-OES: investigation of the calcium, sodium and potassium distribution in tobacco plant stems and leaf petioles, Metallomics, 9/6 (2017) 676-684. doi: 10.1039/C7MT00003K
Oliver Hachmöller, Michaela Aichler, Kristina Schwamborn, Lisa Lutz, Martin Werner , Michael Sperling, Axel Walch and Uwe Karst, Investigating the influnce of standard staining procedures on the copper distribution and concentration in Wilson's disease liver samples by laser ablation-inductively coupled plasma-mass spectrometry, J. Trace Elem. Med. Biol., 44 (2017) 71–75. DOI: 10.1016/j.jtemb.2017.06.002
Oliver Hachmöller, Andree Zibert, Hans Zischka, Michael Sperling, Sara Reinartz Groba, Inga Grünewald, Eva Wardelmann, Hartmut H.-J. Schmidt, Uwe Karst, Spatial investigation of the elemental distribution in Wilson’s disease liver after D-penicillamine treatment by LA-ICP-MS, J. Trace Elem. Med. Biol., 44 (2017) 26-31. DOI: 10.1016/j.jtemb.2017.05.008
Oliver Hachmöller, Ana Guilherme Buzanich, Michaela Aichler, Martin Radtke, Dörthe Dietrich, Kristina Schwamborn, Lisa Lutz, Martin Werner, Michael Sperling, Axel Walch and Uwe Karst, Elemental bioimaging and speciation analysis for the investigation of Wilson’s disease using µXRF and XANES, Metallomics, 8 (2016) 648-653. DOI: 10.1039/c6mt00001k
Oliver Hachmöller, Michaela Aichler, Kristina Schwamborn, Lisa Lutz, Martin Werner, Michael Sperling, Axel Walch, Uwe Karst, Element bioimaging of liver needle biopsy specimens from patients with Wilson’s disease by laser ablation-inductively coupled plasma-mass spectrometry, J. Trace Elem. Med. Biol., 35 (2016) 97–102. DOI: 10.1016/j.jtemb.2016.02.001
Jens Hogeback, Miriam Schwarzer, Christoph A. Wehe, Michael Sperling and Uwe Karst, Investigating the adduct formation of organic mercury species with carbonic anhydrase and hemoglobin from human red blood cell hemolysate by means of LC/ESI-TOF-MS and LC/ICP-MS, Metallomics, 8 (2016) 101-107. DOI: 10.1039/c5mt00186b
2015
Chun Kong Mak, Christoph A. Wehe, Michael Sperling, Uwe Karst, Identification and quantification of electrochemically generated metabolites of thyroxine by means of liquid chromatography/electrospray-mass spectrometry and countergradient liquid chromatography/inductively coupled plasma-mass spectrometry, J. Chromatogr. A, 1419 (2015) 81–88. DOI: 10.1016/j.chroma.2015.09.076
C. Köppen, O. Reifschneider, I. Castanheira, M. Sperling, U. Karst and G. Ciarimboli, Quantitative imaging of platinum based on laser ablation-inductively coupled plasma-mass spectrometry to investigate toxic side effects of cisplatin, Metallomics, 7 (2015) 1595-1603. DOI: 10.1039/c5mt00226e
Rebecca Niehaus, Michael Sperling and Uwe Karst, Study on aerosol characteristics and fractionation effects of organic standard materials for bioimaging by means of LA-ICP-MS, J. Anal. At. Spectrom., 30 (2015) 2056-2065. DOI: 10.1039/c5ja00221d
Christoph A. Wehe, Georgina M. Thyssen, Christina Herdering, Indra Raj, Giuliano Ciarimboli, Michael Sperling, Uwe Karst, Elemental Bioimaging by Means of Fast Scanning Laser Ablation-Inductively Coupled Plasma-Mass Spectrometry, J. Am. Soc. Mass Spectrom. 26/8 (2015) 1274-1282. DOI: 10.1007/s13361-015-1141-y
Olga Reifschneider, Kristina S. Wentker, Klaus Strobel, Rebecca Schmidt, Max Masthoff, Michael Sperling, Cornelius Faber, Uwe Karst, Elemental Bioimaging of Thulium in Mouse Tissues by Laser Ablation-ICPMS as a Complementary Method to Heteronuclear Proton Magnetic Resonance Imaging for Cell Tracking Experiments, Anal. Chem. , 87 (2015) 4225-4230. DOI: 10.1021/ac504363q Olga Reifschneider, Christian L. Schütz, Christoph Brochhausen, Gabriele Hampel, Tobias Ross, Michael Sperling, Uwe Karst, Quantitative bioimaging of p-boronophenylalanine in thin liver tissue sections as a tool for treatment planning in boron neutron capture therapy, Anal. Bioanal. Chem. 407 (2015) 2365–2371. DOI 10.1007/s00216-014-8012-4
Marvin Birka, Kristina S. Wentker, Elke Lusmöller, Brigit Arheilger, Christoph A. Wehe, Michael Sperling, Rudolf Stadler, Uwe Karst,Diagnosis of Nephrogenic Systemic Fibrosis by means of Elemental Bioimaging and Speciation Analysis, Anal. Chem. 87 (2015) 3321-3328. DOI: 10.1021/ac504488k
Christoph A. Wehe, Ann-Christin Niehoff, Georgina M. Thyssen, Michael Sperling, Uwe Karst, Rapid cell mode switching and dual laser ablation inductively coupled plasma mass spectrometry for elemental bioimaging, Rapid Commun. Mass Spectrom., 28 (2014) 2627–2635. DOI: 10.1002/rcm.7054
Franziska Blaske, Olga Reifschneider, Georg Gosheger, Christoph A. Wehe, Michael Sperling, Uwe Karst, Gregor Hauschild, Steffen Höll, Elemental Bioimaging of Nanosilver-Coated Prostheses Using X-ray Fluorescence Spectroscopy and Laser Ablation-Inductively Coupled Plasma-Mass Spectrometry, Anal. Chem., 86 (2014) 615-620. doi: 10.1021/ac4028577
Sascha Nowak, Monika Gesell, Michael Holtkamp, Andy Scheffer, Michael Sperling, Uwe Karst, Wolfgang Buscher, Low gas flow inductively coupled plasma optical emission spectrometry for the analysis of food samples after microwave digestion, Talanta, 129 (2014) 575–578. doi: 10.1016/j.talanta.2014.06.045
Ann-Christin Bülter, Aline Moosmann, Judith Söbbing, Arno Wiehe, Dennis Mulac, Christoph Alexander Wehe, Olga Reifschneider, Franziska Blaske, Sylvia Wagner, Michael Sperling, Hagen von Briesen, Klaus Langer, Uwe Karst, A Palladium Label to Monitor Nanoparticle-Assisted Drug Delivery of a Photosensitizer into Tumor Spheroids by Elemental Bioimaging, Metallomics, 6/1 (2014) 77-81. DOI: 10.1039/C3MT00223C
2013
Christina Herdering, Olga Reifschneider, Christoph A. Wehe, Michael Sperling, Uwe Karst, Ambient molecular imaging by laser ablation atmospheric pressure chemical ionization mass spectrometry, Rapid Commun. Mass Spectrom., 27 (2013) 2595–2600. DOI: 10.1002/rcm.6727
Christina Herdering, Christoph A. Wehe, Olga Reifschneider, Indra Raj, Giuliano Ciarimboli, Kurt Diebold, Christoph Becker, Michael Sperling, Uwe Karst,
Laser ablation based bioimaging with simultaneous elemental and
molecular mass spectrometry: towards spatially resolved speciation
analysis, Rapid Commun. Mass Spectrom., 27 (2013) 2588–2594. DOI: 10.1002/rcm.6726
Olga Reifschneider, Christoph A. Wehe, Indra Raj, Jens Ehmcke, Giuliano Ciarimboli, Michael Sperling, Uwe Karst, Quantitative bioimaging of platinum in polymer embedded mouse organs using laser ablation ICP-MS, Metallomics, 5 (2013) 1440-1447. DOI: 10.1039/c3mt00147d
Marvin Birka, Christoph A. Wehe, Lena Telgmann, Michael Sperling, Uwe Karst, Sensitive quantification of gadolinium-based magnetic resonance imaging contrast agents in surface waters using hydrophilic interaction liquid chromatography and inductively coupled plasma sector field mass spectrometry, J. Chromatogr. A, 1308 (2013) 125-131. DOI: 10.1016/j.chroma.2013.08.017
Christine Brauckmann, Helene Faber, Claudia Lanvers-Kaminsky, Michael Sperling,Uwe Karst, Influence of cimetidine and its metabolites on Cisplatin—Investigation of adduct formation by means of electrochemistry/liquid chromatography/electrospray mass spectrometry, J. Chromatogr. A., 1279 (2013) 49–57. DOI: 10.1016/j.chroma.2012.12.069
L. Telgmann, C.A. Wehe, J. Künnemeyer, A.-C. Bülter, M. Sperling, U. Karst, Speciation of Gd-based MRI contrast agents and potential products of transmetalation with iron ions or parenteral iron supplements, Anal. Bioanal. Chem., 404 (2012) 2133-2141. DOI: 10.1007/S00216-012-6404-X
M. Holtkamp, C.A. Wehe, F. Blaske, C. Holtschulte, M. Sperling, U. Karst, Nitrogen purged TXRF for the quantification of silver and palladium, J. Anal. Atomic Spectrom., 27 (2012) 1799-1802. DOI: 10.1039/C2JA30117B
Lena Telgmann, H. Faber, S. Jahn, D. Melles, H. Simon, M. Sperling, U. Karst, Identification and Quantification of Potential Metabolites of Gd-Based Contrast Agents by Electrochemistry/Separations/Mass Spectrometry, J. Chromatogr. A, 1240 (2012) 147–155.DOI: 10.1016/J.CHROMA.2012.03.088
L. Telgmann, M. Holtkamp, J. Künnemeyer, C. Gelhard, M. Hartmann, A. Klose, M. Sperling, U. Karst, Simple and rapid quantification of gadolinium in urine and blood plasma samples by means of total reflection X-ray fluorescence (TXRF), Metallomics, 30 (2011) 1766-1773. DOI: 10.1039/c1mt00054c
R. Janzen, M. Schwarzer, M. Sperling, M. Vogel, T. Schwerdtle, U. Karst,Adduct formation of Thimerosal with human and rat hemoglobin: a study using liquid chromatography coupled to electrospray time-of-flight mass spectrometry (LC/ESI-TOF-MS), Metallomics, 3/8 (2011) 847–852. DOI: 10.1039/C1MT00043H
A. Wilken, R. Janzen, M. Holtkamp, S. Nowak, M. Sperling, M. Vogel, U. Karst,Investigation of the interaction of Mercurochrome constituents with proteins using liquid chromatography/mass spectrometry, Anal. Bioanal. Chem., 397 (2010) 3525-3532. DOI: 10.1007/S00216-010-3842-1
M. Sperling, W. Buscher, O.F.X. Donard,R. Cornelis, L. Ebdon, Transfer of Know-how and Knowledge in the Area of Speciation Analysis from research Institutions to Industry - The European Virtual Institute for Speciation Analysis (EVISA), RMZ-Materials and Geoenvironment, 51 (2004) 2030-2032.