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Instrument Database:
Thermo Scientific - Q Exactive™ Plus Hybrid Quadrupole-Orbitrap™ Mass Spectrometer
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| Year of introduction |
2013 |
| Status |
available |
| Company |
Thermo Scientific
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| Categories |
Hyphenated Techniques: LC-MS
Mass spectrometer: ESI-MS
Mass spectrometer: LC-MS
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The Thermo Scientific™ Q Exactive™ Hybrid Quadrupole-Orbitrap™ Mass Spectrometer introduced the revolutionary concept of Quanfirmation. The Thermo Scientific™ Q Exactive™ Plus Hybrid Quadrupole-Orbitrap™ Mass Spectrometer takes Quanfirmation to the next level with increased performance and new options that enhance applications from confident DMPK qual/quan screening studies to characterization of intact monoclonal antibodies. - See more at: http://www.thermoscientific.com/en/product/q-exactive-plus-hybrid-quadrupole-orbitrap-mass-spectrometer.html#sthash.jc9224mo.dpuf The Thermo Scientific™ Q Exactive™ Hybrid Quadrupole-Orbitrap™ Mass Spectrometer introduced the revolutionary concept of Quanfirmation. The Thermo Scientific™ Q Exactive™ Plus Hybrid Quadrupole-Orbitrap™ Mass Spectrometer takes Quanfirmation to the next level with increased performance and new options that enhance applications from confident DMPK qual/quan screening studies to characterization of intact monoclonal antibodies.
Superior Quantitation
- Advanced quadrupole technology (AQT) improves precursor selection and transmission for more-accurate quantitation of low-abundance analytes in complex matrices
- Sophisticated data-independent acquisition (DIA) and parallel reaction monitoring (PRM) deliver reproducible quantitation with complete qualitative confidence
- An advanced active beam guide (AABG) reduces noise and extends maintenance intervals
Enhanced Analysis of Intact Proteins
- Optional intact protein mode provides superior trapping of large molecules for improved analysis of intact proteins and protein complexes
- Optional enhanced resolution ensures maximum ID confidence in top-down proteomics and lipidomics
High-Confidence Results
- HR/AM and full-scan capabilities capture all sample data, all of the time, enabling retrospective data analysis without need to re-run samples
- Resolving power up to 140,000 FWHM eliminates isobaric interferences, increasing confidence in results when analyzing samples in complex matrices
- Better than 1ppm mass accuracy in full- and all-ion fragmentation (AIF) scan modes ensures confident compound identification
- Fast scanning at 12Hz and spectral multiplexing suited to UHPLC applications
- Rapid polarity switching maximizes information obtained
- AIF and multiple dissociation techniques — in-source CID and HCD — aid in compound identification
- Mass range to 6,000 m/z enhances detection of singly charged small molecules and biomolecules
- More than four orders of magnitude intrascan dynamic range, along with femtogram-level sensitivity, allow detection of trace-level and high-abundance compounds in the same scan
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| Specifications |
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Mass Range m/z
| 50 to 6000
| Dynamic Range
| >5000:1
| | Mass Accuracy | Internal calibration: <1ppm RMS External calibration: <3ppm RMS
| Polarity Switching
| One full cycle in <1s (one full scan positive mode and one full scan negative mode) at resolution 35,000
| Sensitivity
| Full MS: 500fg buspirone on column S/N 100:1, SIM: 30fg Buspirone on column S/N 100:1
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Mass Range m/z 50 to 6000 Dynamic Range >5000:1 Mass Accuracy Internal calibration: <1ppm RMS, External calibration: <3ppm RMS Polarity Switching One full cycle in <1s (one full scan positive mode and one full scan negative mode) at resolution 35,000 Sensitivity Full MS: 500fg buspirone on column S/N 100:1, SIM: 30fg Buspirone on column S/N 100:1 - See more at: http://www.thermoscientific.com/en/product/q-exactive-plus-hybrid-quadrupole-orbitrap-mass-spectrometer.html#sthash.jc9224mo.dpuf
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