Thermo Scientific - Q Exactive™ HF-X Hybrid Quadrupole-Orbitrap™ Mass Spectrometer

The Thermo Scientific™ Q Exactive™ HF-X Hybrid Quadrupole-Orbitrap™ Mass Spectrometer rises to the occasion and sets new standards in sensitivity, performance and productivity. The Q Exactive HF-X Mass Spectrometer uses a high-capacity transfer tube for maximum ion loading, an electrodynamic ion funnel that accomodates and transmits ions over a broader mass range, and a high-field Thermo Scientific™ Orbitrap™ mass analyzer. Together, these components enable fast identification and analysis of peptides, label-free and TMT quantitation, top-down proteomics analyses, sophisticated DDA and DIA, dynamic Retention Time PRM and BioPharma characterization.

Smart, Consistent and Productive

• Novel architecture, including a high capacity transfer tube (HCTT) and electrodynamic ion funnel, increase ion transmission and boost sensitivity for all analytes ranging from small molecules to native antibodies.
• Superior consistency and performance set new standards for quantitative accuracy, sensitivity and reproducibility, facilitating even the most rigorous research workflows during large-scale studies of challenging protein samples.
• Functional versatility enables the use of this single, high-performance platform in both bottom-up and top-down proteomics studies.
• Increased acquisition speed and a sophisticated DDA+ workflow dramatically improve peptide sequencing speed and depth.
• Robust workflows advance biomarker verification and analysis via parallel reaction monitoring (PRM), with high-resolution data-independent acquisition (DIA) and automated retention time correction.
• Available with the powerful Thermo Scientific™ Q Exactive™ BioPharma option to support all workflows in biotherapeutics characterization with enhanced sensitivity, from peptide mapping to analysis of intact proteins under native conditions.