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Instrument Database:
Thermo Scientific - Orbitrap Astral Mass Spectrometer
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| Year of introduction |
2023 |
| Status |
available |
| Company |
Thermo Scientific
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| Categories |
Mass spectrometer: ESI-MS
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The Orbitrap Astral Mass Spectrometer combines three mass analyzers: a quadrupole mass analyzer for high selectivity and high ion transmission, an Orbitrap mass analyzer for high dynamic range and high resolution measurements, and the novel Astral analyzer for fast and sensitive measurements. By combining these three mass analyzers and orchestrating the coordination of 5 separate ion packets within the instrument in parallel a new standard for mass spectrometry performance is achieved to unlock new insights into biology and disease mechanisms Benefits
- Faster throughput with shorter gradients due to higher HRAM MS/MS sensitivity, dynamic range, and acquisition rate
- Deeper coverage due to higher HRAM MS/MS sensitivity, dynamic range, and faster acquisition rate
- Higher sensitivity measurements with the Astral mass analyzer for low sample input, including single cell experiments
- Accurate and precise quantitation for label-free quantitation (LFQ) and Tandem Mass Tag™ (TMT™) analyses across a broader dynamic range
- BioPharma option for comprehensive analysis of native protein complexes
- Full experimental flexibility with revolutionary instrument control software
- Common user interface with Thermo Scientific™ Orbitrap Exploris™, Thermo Scientific™ Orbitrap Tribrid™, and Thermo Scientific™ TSQ™ Triple Quadrupole mass spectrometers
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| Specifications |
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Performane specifications - Orbitrap analyzer Orbitrap mass range
| Standard mass range m/z 40–6,000, m/z 40–8,000 with BioPharma option
| | Orbitrap resolution | Standard resolution settings range from 7,500 to 480,000 (FWHM) at m/z 200, with isotopic fidelity up to 240,000 FWHM
| Acquisition rate*
| Orbitrap MS2 acquisition rates up to 40 Hz when measured using a data-dependent experiment with FlexMix calibration solution, MS and HCD MS/MS resolution setting of 7,500 @ m/z 200 | Orbitrap mass accuracy*
| External calibration achieves <3 ppm RMS drift over 24 hours, measured with Pierce™ FlexMix™ Calibration Solution; internal calibration achieves <1 ppm RMS drift over 24 hours, measured with FlexMix Calibration Solution
| MS/MS Electrospray Ionization (ESI)
Orbitrap sensitivity
| MS/MS: 50 fg reserpine on column S/N 100:1 SIM: 50 fg reserpine on column S/N 150:1 | Dynamic range
| >5,000 within a single microscran Orbitrap mass spectrum
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Performane specifications - Astral analyzer
Astral mass range
| Standard mass range m/z 40–6,000
| | Astral resolution* | 80,000 FWHM at m/z 524 | Acquisition rate*
| Astral MS2 acquisition rates up to 200 Hz with a maximum injection time of 3 ms Astral mass | Astral mass accuracy *
| External calibration achieves <5 ppm RMS drift over 24 hours, measured with FlexMix Calibration Solution | | Dynamic range | >1,000 within a single microscan Astral mass spectrum
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* Under defined conditions
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