|
Instrument Database:
Foss A/S - Rapid Content Analyzer
| |
|
|
| |
|
| |
|
| Year of introduction |
|
| Status |
available |
| Company |
Foss A/S
|
| Categories |
Spectrometer ( Molec. ): NIR
|
The Rapid Content Analyzer is a true multipurpose analyser used to analyse powders, liquids, or finished dosage forms without requiring a change to the instrument. Analyse incoming raw material powders or liquids directly in vials, bottles, beakers, or sample bags for identification and qualification in seconds.
Benefits and features
- Non-destructive analysis of solids and liquids in less than one minute
- Direct analysis through unopened containers, such as bags, pouches, vials, bottles, jars, and beakers No sample preparation, no hazardous reagents, no waste
- Raw material identification and qualification
- Final product assay.
System Description
The Rapid Content Analyzer offers fast, cost-effective testing of a whole range of pharmaceutical manufacturing applications. Based on near-infrared (NIR) technology, sample analysis is non-destructive, and does not require sample preparation or hazardous reagents.
The Rapid Content Analyzer is a true multipurpose analyser and can be used to analyse powders, liquids, or finished dosage forms without requiring a change to the instrument. Analyse incoming raw material powders or liquids directly in vials, bottles, beakers, or sample bags for identification and qualification in seconds. This fiber-based sampling system allows for a circular beam to illuminate the sample. A ring of detectors positioned around the fiber beam yields the maximum detection area. Insensitivity to sample position is also achieved with this detector arrangement. The NIR method can identify and qualify materials as acceptable, eliminating most other tests and reducing the time in quarantine from days to minutes.
Measure parameters such as moisture in hazardous actives directly through the walls of an unopened vial, to protect both the material and the analyst. Analyse lyophilized powders and cakes in the vial just as easily. Compare a 20-second moisture analysis by NIR to a 30-minute Karl Fischer titration. Accuracy is equal, while NIR precision is usually better. The speed and turn-around rate of NIR make it the logical choice.
Analyse tablets and other solid dosage forms non-destructively for correlation with content uniformity and dissolution testing. Also, develop NIR calibration methods for monitoring active and excipient concentrations. Once the calibrations are developed, operation of the instrument is handled simply and without extensive set-up.
|
| Specifications |
|
Scan Rate
1.8 scans/second
Wavelength Range
1100-2500nm (Standard Mode)400-2500nm (Wide-Range Mode)
Wavelength Accuracy
±0.3nm (Basis: Polystyrene Standard peaks 1100-2500nm)
Wavelength Repeatability
±0.010nm (Standard Deviation of 10 consecutive scans 1100-2500nm
Noise (peak-to-peak)
<3.0 (400-700nm) <.4 (700-2500nm)
Noise (RMS Avg)
<.2 (400-700nm) <.04 (700-2500nm)
Spectral Bandwidth
10 ± 1nm
Photometric Range
3.0 Au (1100-2500nm)
Linearity (2% to 99% reflectivity or transmissivity)
±1.0%
Stray Light
Less than 0.1% at 2300nm
Operating Temperature Range
15°C to 33°C (60°F to 92°F)
Power Consumption
150 watts (maximum)
|
|
