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The establishment of EVISA is funded by the EU through the Fifth Framework Programme (G7RT- CT- 2002- 05112).

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multiple reaction monitoring

Multiple reaction monitoring (MRM) is an MS/MS experiment that uses two sequential stages of independent mass analysis. In the product ion MS/MS scan, a precursor ion is selected by mass with the first mass analyzer, and the fragment ions formed as a result of collision-induced  dissociation are measured with a scan of the second mass analyzer and recorded in a mass spectrum. In an analogy to selected ion monitoring, if both mass analyzers in an MS/MS  instrument are set on a specific mass, the signal represents the precursor-to-product ion transition for a specific ion pair. This experiment is called reaction monitoring. If several  different precursor–product ion pairs are monitored, as is most often the case, the experiment is multiple reaction monitoring.

The term "multiple reaction monitoring" was found in the following pages:


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