The Thermo Scientific™ Orbitrap Exploris™ 120 mass spectrometer is a Thermo Scientific™ quadrupole-Orbitrap™ mass spectrometer which is based on proven hardware and instrument control software designs of next-generation Thermo Scientific™ mass spectrometers and incorporates extensive customer and service engineer feedback.1The Orbitrap Exploris 120 mass spectrometer extends the Thermo Scientific Orbitrap Exploris mass spectrometer portfolio, with productivity made easy and rugged for laboratories performing high-throughput targeted screening and quantitation. High-resolution accurate-mass (HRAM) capability provides the fast path to accurate results in a solution with everyday operational usability and consistent performance.
Benefits
- Keep your laboratory runningseamlessly with single-clickcalibration lasting at least five daysand maximum mass accuracyusing built-in Thermo Scientific™EASY-IC™ ion source internalreference mass
- Focus on your science, notinstrument set up with intuitivetuning, drag-and-drop methodsetup, and predefined experimentsdriven by next-generation software
- Process more samples withimproved scan speed and fastpolarity switching
- Improve space utilization anddeliver maximum business valuewith compact footprint whenbench-top space is limited
Hardware features
Ion source
Thermo Scientific™ OptaMax™ NG ion source
- Ultimate sensitivity with an efficient, heated electrospray ionization (H-ESI II) probe to deliver maximum performance with minimal optimization
- Additional non-heated low-flow calibrant sprayer for optimal mass and system calibration
- Enhanced system ruggedness and reduced chemical noise with sweep gas
- Flow rates from 1 μL/min to 1,000 μL/min; OPTON-30139 (low-flow needle; 1–10 μL/min), OPTON-30694 (high-flow needle; 5–1,000 μL/min)
Ion optics
The atmospheric pressure ionization (API) interface consists of:Round bore transfer tube
- Removable, heated ion transfer tube
- Vent-free maintenance
S-lens
Progressively spaced stacked-ring ion guide (S-Lens) captures and efficiently focuses ions into a tight beam while minimizing in-source dissociation. Large variable spacing between electrodes allows for better pumping efficiency and improved ruggedness.
Advanced active beam guide (AABG)
Axial field and injection filtering reduce noise by preventingneutrals and high-velocity clusters from entering the quadrupole mass filter using a double bent design geometry
Advanced quadrupole technology (AQT)
- Segmented quadrupole mass filter for precursor ion selection with variable precursor isolation width from 0.4 to 1200 Da
- MS/MS precursor ion selection with high transmission from m/z 40 to 2,000Ion-routing multipole (IRM)
- Robust ion trapping for MS scans and higher energy collisional dissociation (HCD)
- Selection of absolute collision energy (CE) or normalizedcollision energy (NCE) for precursor fragmentation
- Nitrogen collision gas
Automatic gain control (AGC)
Reliable AGC measurements for controlled injection of the number of ions is ensured by the novel Independent Charge Detector
Thermo Scientific™ Orbitrap™ mass analyzer
- High-field Orbitrap mass analyzer
- Low-noise-detection pre-amplifier
- 4kV central electrode voltage
Vacuum system
- A compact single turbo pump design provides the adequate vacuum in six stages for the aluminum high-vacuum analyzer chambers
- Advanced vacuum technology reduces pressure in the ultra-high vacuum regions, enhancing transmission of ions to the Orbitrap mass analyzer
Thermo Scientific™ EASY-IC™ ion source
- Provides <1 ppm RMS mass accuracy under defined conditions with minimum effort for at least five days
- Generates optional internal reference ions for real-time mass correction of spectra in both positive and negative modes
Optional hardware
APCI probe for OptaMax NG ion source
- Compatible with flow rates from 50 μL/min to 1,000 μL/min without splitting
- The APCI probe can be upgraded to APPI
